Amatuximab

产品活性：Amatuximab(MORab-009)isachimeric,humanizedIgG1/kMAbthattargetsthecellsurfacemesothelin(MSLN).Mesothelinisaglycosylphosphatidylinositol(GPI)-anchoredmembraneglycoprotein,whichispresentinarestrictedsetofnormaladulttissuessuchasthemesothelium.

研究领域：Immunology/Inflammation

作用靶点：Mesothelin

InVitro:Amatuximab(MORAb-009)isamouse-humanchimericmonoclonalantibodywithaselectiveaffinityforMSLN.Invitro,amatuximabelicitsantibody-dependentcellularcytotoxicity(ADCC)againstmesothelinexpressingtumorcelllinesandinhibitsheterotypiccelladhesionofmesothelin-positivetumorcellstoCA125-expressingtumorcells.

InVivo:Intumorxenograftstudies,combinationtreatmentwithamatuximabpluschemotherapyledtoagreaterreductioninthegrowthofmesothelin-expressingtumorsthaneitherAmatuximaborchemotherapyalone.

Amatuximab

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